EULAR/ACR SLE Criteria (2019)

Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Introduced the ANA entry criterion, the ten weighted domains, and the threshold of ≥ 10 points with at least one clinical criterion used here; sensitivity 96.1% and specificity 93.4% in the validation cohort (696 SLE, 574 controls). Published simultaneously in Arthritis & Rheumatology 2019;71(9):1400–1412 and Annals of the Rheumatic Diseases 2019;78(9):1151–1159.

These are classification criteria, developed to define homogeneous groups for research; they are not diagnostic criteria and must not be used to withhold treatment from a patient who does not fully meet them (including persistently ANA-negative disease). A criterion is counted only if SLE is the most likely explanation for it, so infection, drugs, and other causes must be considered first — fever in particular. Criteria may have occurred at any time and need not be simultaneous. The cohorts included few children and few patients with skin-predominant disease, so performance in those groups is less well established. The 2012 SLICC criteria are available separately in this app.