الدالة التمييزية لمادري

Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr. Corticosteroid therapy of alcoholic hepatitis. Introduced the discriminant function combining prothrombin time and bilirubin; patients with a high value had substantial short-term mortality and appeared to benefit most from corticosteroids.

Carithers RL Jr, Herlong HF, Diehl AM, et al. Methylprednisolone therapy in patients with severe alcoholic hepatitis. Used the modified discriminant function 4.6·(PT − control) + bilirubin with a threshold of 32 to define severe disease; corticosteroids reduced 28-day mortality in that group.

AASLD and EASL guidance use mDF ≥ 32 (or MELD > 20) to identify severe alcohol-associated hepatitis for consideration of corticosteroids, with the Lille score at day 7 used to decide whether to continue them.