CLL Staging — Rai & Binet

Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Stages 0–IV: lymphocytosis alone; with lymphadenopathy; with hepatomegaly or splenomegaly; with anaemia (haemoglobin < 11 g/dL); with thrombocytopenia (< 100,000/mm³).

Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Stages A, B and C from the number of involved areas (cervical, axillary and inguinal nodes, spleen, liver) and haemoglobin < 10 g/dL or platelets < 100 × 10⁹/L.

PDQ® Adult Treatment Editorial Board. Chronic Lymphocytic Leukemia Treatment (PDQ®) – Health Professional Version. National Cancer Institute — Rai and Binet tables (its Binet footnote lists four areas, without the liver). Modified Rai risk groups: low (0), intermediate (I–II), high (III–IV). Immune-mediated cytopenias do not count toward stage III/IV or C. Staging assumes a confirmed CLL diagnosis.