De Ritis Ratio (AST/ALT)

De Ritis F, Coltorti M, Giusti G. An enzymic test for the diagnosis of viral hepatitis; the transaminase serum activities. Introduced the AST/ALT (SGOT/SGPT) ratio that carries De Ritis’ name.

Williams AL, Hoofnagle JH. Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis. The ratio is usually > 2.0 in alcoholic liver disease and < 1.0 in chronic hepatitis and cholestatic syndromes; in non-alcoholic chronic liver disease a ratio > 1.0 should suggest cirrhosis, and cirrhosis makes the ratio less helpful for separating alcoholic from non-alcoholic disease.