Liver (bilirubin)
< 1.2 mg/dL (< 20 µmol/L)
1.2–1.9 mg/dL (20–32 µmol/L)
2.0–5.9 mg/dL (33–101 µmol/L)
6.0–11.9 mg/dL (102–204 µmol/L)
≥ 12.0 mg/dL (> 204 µmol/L)
Cardiovascular (MAP / vasopressors)
Dopamine ≤ 5 or any dobutamine
Dopamine > 5, or epinephrine ≤ 0.1, or norepinephrine ≤ 0.1
Dopamine > 15, or epinephrine > 0.1, or norepinephrine > 0.1
Renal (creatinine / urine output)
< 1.2 mg/dL (< 110 µmol/L)
1.2–1.9 mg/dL (110–170 µmol/L)
2.0–3.4 mg/dL (171–299 µmol/L)
3.5–4.9 mg/dL (300–440 µmol/L) or urine < 500 mL/day
≥ 5.0 mg/dL (> 440 µmol/L) or urine < 200 mL/day
Evidence
Original publication
Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Grades six organ systems (respiration, coagulation, liver, cardiovascular, CNS, renal) from 0 to 4 using the worst daily value.
Intensive Care Medicine, 1996
Validation
Ferreira FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. Higher initial, highest, and delta SOFA scores tracked ICU mortality; total > 15 corresponded to > 80% mortality.
JAMA, 2001
Guideline
Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3): sepsis is defined as infection plus an acute rise in SOFA of ≥ 2 points.
JAMA, 2016
Last reviewed: 2026-09
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MedScore is an educational and clinical decision-support tool. It does not provide a diagnosis, a treatment, or a drug-dosing recommendation, and it does not replace clinical judgement or local guidelines. Confirm every result against the original source before acting on it. The treating clinician remains responsible for all decisions.