30-day mortality after ST-elevation MI treated with fibrinolysis
Age
< 65 years
65–74 years
≥ 75 years
History of diabetes, hypertension, or angina
Systolic BP < 100 mmHg
Heart rate > 100/min
Killip class II–IV
Weight < 67 kg
Anterior STEMI or new LBBB
Time to treatment > 4 hours
Evidence
Original publication
Morrow DA, Antman EM, Charlesworth A, et al. TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation (InTIME II substudy). Ten weighted variables predicted 30-day mortality, which rose more than 40-fold from a score of 0 to > 8.
Circulation, 2000
Open source
Guideline
Validated in the TIMI 9 and NRMI registries and used in ACC/AHA STEMI risk communication; the mortality figures here are for fibrinolytic-treated patients and overestimate risk in a primary-PCI pathway.
Last reviewed: 2026-09
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