Gleason Score / Grade Group

Prostate adenocarcinoma grading — primary + secondary pattern, Grade Group 1–5
Primary (most prevalent) pattern
Secondary (second most prevalent) pattern
Select the primary and secondary Gleason pattern
Evidence
Original publication
Epstein JI, Egevad L, Amin MB, et al. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system. Defined the five Grade Groups derived from the Gleason score.
American Journal of Surgical Pathology, 2016
Open source
Validation
Epstein JI, Zelefsky MJ, Sjoberg DD, et al. A contemporary prostate cancer grading system: a validated alternative to the Gleason score. In > 20 000 men the Grade Groups showed a monotonic, well-separated relationship with biochemical recurrence after prostatectomy or radiotherapy.
European Urology, 2016
Open source
Guideline
Grade Group is now reported alongside the Gleason score in the AJCC 8th edition and NCCN/EAU risk stratification. On needle biopsy the highest-grade core is generally used; a small amount of high-grade pattern (tertiary pattern 5) is reported separately and can raise the effective risk. Grading is a pathologist's assessment of the specimen — this tool only maps the reported patterns to the score and group.
Last reviewed: 2026-09
Report an error in this calculator
MedScore is an educational and clinical decision-support tool. It does not provide a diagnosis, a treatment, or a drug-dosing recommendation, and it does not replace clinical judgement or local guidelines. Confirm every result against the original source before acting on it. The treating clinician remains responsible for all decisions.