Bicarbonate Buffer Amount

Rehm M, Hofmann-Kiefer K, Conzen P. Blutgasanalyse. In: Marx G, Muhl E, Zacharowski K, et al., eds. Die Intensivmedizin. Berlin, Heidelberg: Springer; 2015 (DOI 10.1007/978-3-642-54675-4_26). Gives NaHCO₃ [mmol] = SBE × 0.2 × body weight [kg], the factor 0.2 being the extracellular share of body weight; for THAM the same chapter uses 0.3. Book chapter, no PubMed record.

Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. In clinical studies of lactic acidosis and ketoacidosis, bicarbonate administration has not reduced morbidity or mortality or improved cellular function; the amount calculated here is an estimate of the base deficit, not evidence that replacing it helps.